Evaluation of Antileishmanial Activity of Osteospermum ecklonis Extract of Aerial Parts against Leishmania donovani: in vitro(Conference Paper) #

Abstract
 
 Lack of safe available non-resistant treatment for visceral leishmaniasis (Kala-azar) keeps limiting the complete cure this disease ,drugs that have toxic side effects or lack effectiveness led to relapse ,all these factors lightened way search imperative drugs from natural resources been shown antileishmanial activity through literature survey
 . In present study, comparative in vitro anti-leishmania various fractions Osteospermum ecklonis aerial parts evaluated. Extracts were prepared maceration and Soxhlet apparatus using 85% methanol fractionation was done by separating active constituents according differences their polarities petroleum ether n-butanol respectively. The resultant fractions( as well )were chosen effective inhibition Leishmania donovani, results prove with no doubt fraction a concentration 2.5 mg/ml had better than other concentrations tested samples result coincided anti-leishmaniasis official (pentostam®) ,This finding can be attributed terpene nature materials used existed such fraction. This observation paved road step extended studies relation conventional herbal medicines alternatives synthetic chemical drugs.